More than a ‘speed gene’: ACTN3 R577X genotype, trainability, muscle damage, and the risk for injuries
نویسندگان
چکیده
منابع مشابه
ACTN3: More than Just a Gene for Speed
Over the last couple of decades, research has focused on attempting to understand the genetic influence on sports performance. This has led to the identification of a number of candidate genes which may help differentiate between elite and non-elite athletes. One of the most promising genes in that regard is ACTN3, which has commonly been referred to as "a gene for speed". Recent research has e...
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Background VEGF gene has been reported to be related with many diseases and recurrent pregnancy loss in various studies. VEGF polymorphisms are risk factors for pregnancy losses, and generally studies report only women’s genetic analyses. To evaluate the association between VEGF A C405G, C460T, C936T and C2578A polymorphisms and spontaneous abortion, we studied the genotypes of spontaneously a...
متن کاملACTN3 (R577X) genotype is associated with fiber type distribution.
alpha-Actinin-3 is a Z-disc structural protein found only in type II muscle fibers. The X allele of the R577X polymorphism in the ACTN3 gene results in a premature stop codon and alpha-actinin-3 deficiency in XX homozygotes. Associations between the R577X polymorphism and the muscle-power performance of elite athletes have been described earlier. About 45% of the fiber type proportions are dete...
متن کاملACTN3 and MLCK genotype associations with exertional muscle damage.
Strenuous exercise results in damage to skeletal muscle that is manifested in delayed muscle pain, prolonged strength loss, and increases in muscle proteins in the blood, especially creatine kinase (CK) and myoglobin (Mb). Some individuals experience profound changes in these variables in response to standard laboratory exercise or recreational activities. We proposed that variations in genes c...
متن کاملGreater muscle damage in athletes with ACTN3 R577X (RS1815739) gene polymorphism after an ultra-endurance race: a pilot study
In this study, we aimed to investigate the influence of ACTN3 R577X gene polymorphism on muscle damage responses in athletes competing in an ultra-endurance race. Twenty moderate to well-trained ultra-runners who had entered in an official 37.1 km adventure race (22.1 km mountain biking, 10.9 km trekking, 4.1 km water trekking, 30 m rope course, and orienteering) volunteered for the study. Bloo...
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ژورنال
عنوان ژورنال: European Journal of Applied Physiology
سال: 2018
ISSN: 1439-6319,1439-6327
DOI: 10.1007/s00421-018-4010-0